@conference {3672,
	title = {Preliminary linkage studies in sheep of keratin and keratin-associated protein genes with fleece weight, wool fibre diameter and fibre curvature},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {75},
	year = {2015},
	month = {07/2015},
	address = {Dunedin},
	abstract = { A linkage study was conducted to detect variations in the genes for keratins and keratin-associated proteins (KRTAP) that might
affect wool traits. To date 93 such genes have been identified in sheep: 85 of them (~91\%) are clustered in three chromosomal
regions. Twenty-one genes are grouped within a 4-Mbp region on sheep chromosome 1 (OAR1), 28 within a 1-Mbp segment on
chromosome 3 (OAR3), and 36 are clustered within a 1.3-Mbp site on chromosome 11 (OAR11). The DNA markers used in this
work were single nucleotide polymorphisms (SNPs) dispersed throughout these keratin and KRTAP gene clusters. Markers were
designed as three SNP-multiplexes: a 25-SNP, a 15-SNP and a 19-SNP multiplex for keratins/KRTAP regions on OAR1, OAR3
and OAR11, respectively. Resource animals came from eleven sire families whose progeny had been phenotyped for greasy fleece
weight, washing yield, fibre curvature and diameter. Between 29 and 45 progeny per sire were genotyped with the three SNPmultiplexes.
Linkage analyses on co-segregation of SNP alleles from sires with wool phenotypes of progeny were done across all
the sires and within sire groups. Based on theoretical genome-wide threshold (F-value 10.13 and nominal P = 0.0016 for withinsire
suggestive level), one family showed suggestive quantitative trait loci for greasy fleece weight on OAR1 and fibre diameter
variability on OAR3. For these experimental animals, the results show no strong evidence of involvement of keratin and KRTAP
genes in the wool characteristics analysed.},
	issn = {1176-5283},
	author = {Phua SH and Scobie DR and O{\textquoteright}Connell D and Henry H and Dodds KG and Brauning R and Clerens S}
}
@conference {89264,
	title = {Genome wide DNA methylation patterns and transcription analysis in sheep muscle},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {73},
	year = {2013},
	month = {Jan},
	pages = {37-40},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Hamilton},
	abstract = {<p>The Carwell phenotype is a desirable inherited muscular hypertrophy of the Longissimus dorsimuscle in Poll Dorset sheep that does not have any detrimental effect on eating quality, fat deposition or detectable meat tenderness. The Carwell haplotype has been localized to a 350kb region on the distal end of OAR18 near the Callipyge locus (Nicoll et al. 1998) containing three known genes. However, in spite of considerable effort in sequencing and resequencing, the causative mutation has not been identified. Although unsuccessful in identifying the causative mutation, these studies have revealed that the Carwell phenotype displays an imprinted inheritance pattern, with increased muscling associated with inheritance from the sire but not the dam.</p>
},
	issn = {1176-5283},
	author = {Couldrey C and Brauning R and MacLean PH and Henderson HV and McEwan JC}
}
@conference {79010,
	title = {Development of epigenomic analysis in agricultural animals},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {72},
	year = {2012},
	month = {Jan},
	pages = {163-165},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Christchurch},
	abstract = {Advances made in DNA sequencing technologies over the past 15 years (Zhao \& Grant 2011) have resulted in genome wide selection for production traits becoming a reality. Soon all sequence variations in each individual in closed breeding schemes will be known. What is not currently known is how to rank these variations, especially those that involve changes in gene expression rather than amino acid sequence. In order to continue making genetic progress we will need an understanding of how epigenetics affects gene expression and ultimately phenotype.},
	issn = {1176-5283},
	author = {Couldrey C and Brauning R and Retzel EF and McEwan JC}
}
