@conference {40563,
	title = {Growth-promoting and metabolic actions of recombinant ovine placental lactogen and bovine growth hormone in young lambs},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {54},
	year = {1994},
	month = {Jan},
	pages = {59-62},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {It has been shown previously that ovine placental lactogen (oPL) has a  
growth-promoting effect in the growth hormone (GH)-deficient dwarf rat.   
However, this effect has not been verified in an homologous system using  
animals with an intact somatotrophic axis.  To examine the effects of oPL in  
the sheep, we injected lambs with recombinant oPL (0.1 mg/kg liveweight/day,  
n=16) or saline (n=16) for 21 days commencing on day 3 of life and compared  
their effects on body growth and energy intake with those in lambs treated with  
the same dose of recombinant bovine growth hormone (bGH, n=16).   
Circulating concentrations (ng/ml) of hormones in saline- vs bGH- vs oPL- 
treated lambs at day 20 of treatment were (mean{\textpm}SE): oPL, <0.5 vs <0.5 vs  
12.8{\textpm}0.5; GH, 10.8{\textpm}5.0 vs 48.4{\textpm}5.0 vs 12.6{\textpm}5.0, P<0.001; insulin-like growth  
factor-I (IGF-1), 267.6{\textpm}14.4 vs 302.4{\textpm}14.2 vs 291.7{\textpm}14.4.  Average daily gain  
(kg/day) during treatment was significantly (P<0.05) greater in oPL-treated  
lambs (0.28{\textpm}0.01) than in saline-treated (0.25{\textpm}0.01) or bGH-treated  
(0.24{\textpm}0.01) lambs.  Similarly, there were significant (P<0.05) increases in 
total energy intake (over the 21 day treatment period) during treatment with 
oPL (112.5{\textpm}3.5 MJ ME), compared with bGH (102.0{\textpm}3.5 MJ ME) or saline  
(102.0{\textpm}3.5 MJ ME) treatment.  It is concluded that oPL is somatogenic in  
young lambs.  This effect may be mediated by stimulating voluntary feed 
intake rather than by elevating circulating concentrations of IGF-I. },
	issn = {1176-5283},
	author = {Min SH and MacKenzie DDS and Breier BH and McCutcheon SN and Gluckman PD}
}
